The ISEA2012 STEMArts curriculum tool was built around and for the International Symposium of Electronic Arts 2012: Machine Wilderness (ISEA2012). It is aligned with the P21 Framework for 21st Century Learning as a teaching tool for middle and high school students. The ISEA2012 curriculum content is organized around the work and personal stories of featured ISEA2012 artists with a focus on STEM, creativity and innovation. These artists from diverse cultural and academic backgrounds dance gracefully across disciplines and have powerful stories to share that can directly inspire and engage our youth. Our Web 2.0 tools compile an array of STEM + Arts activities and resources, harnessing the collective knowledge available online. Our STEM Concept tool provides core ideas from the Next Generation Science Standards. This is reflected in the artists' work, and through a personal perspective on the artists' unique STEM innovations. The curriculum tool should not be considered as a replacement for a teacher’s experience or for teaching STEM subjects, but more as an engaging and stimulating way to develop an understanding of the principals and concepts of STEM and how it contributes to the world we live in. The STEMArts Framework provides meaningful ways to engage youth in developing STEM skills through creativity, while inspiring their passion for learning.